高效液相色谱法测定枳实-白芍配伍的化学成分变化

陈稚; 陈家仪; 贾薇; 崔妙仪; 陈楚源; 关锦涛; 曾元儿; 江滨

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高效液相色谱法测定枳实-白芍配伍的化学成分变化

更新时间：2024-01-04

- 高效液相色谱法测定枳实-白芍配伍的化学成分变化
- Changes of Chemical Components in Compatibility of Citrus Aurantium with Paeoniae Radix Alba
- 中国实验方剂学杂志 2013年19卷第6期页码：138-141
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- 纸质出版日期：2013
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陈稚, 陈家仪, 贾薇, 等. 高效液相色谱法测定枳实-白芍配伍的化学成分变化[J]. 中国实验方剂学杂志, 2013,19(6):138-141.

CHEN Zhi, CHEN Jia-yi, JIA Wei, et al. Changes of Chemical Components in Compatibility of Citrus Aurantium with Paeoniae Radix Alba[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 138-141.
陈稚, 陈家仪, 贾薇, 等. 高效液相色谱法测定枳实-白芍配伍的化学成分变化[J]. 中国实验方剂学杂志, 2013,19(6):138-141. DOI：

CHEN Zhi, CHEN Jia-yi, JIA Wei, et al. Changes of Chemical Components in Compatibility of Citrus Aurantium with Paeoniae Radix Alba[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 138-141. DOI：

摘要

目的: 研究枳实和白芍配伍后化学成分在质和量上的变化。方法: 采用HPLC比较枳实-白芍单煎液与合煎液中各成分的变化

色谱柱为Syncronis-C18(4.6 mm×250 mm

5 μm)

柱温25 ℃

流动相乙腈-0.3%磷酸水溶液

检测波长230 nm。结果: 方法学考察表明

所用色谱条件符合定性和定量研究要求

确定了19个共有峰

并初步对各共有峰进行归属判断

其中8个成分含量增加

而9个成分含量降低。枳实-白芍配伍后化学成分没有发生质的改变

但含量上发生了显著变化。结论: 中药复方的配伍并不是单味中药的简单相加

而是有一定科学依据的。

Abstract

Objective: To study the changes of quality and quantity of chemical components in compatibility of Zhishi Shaoyao Powder. Method: HPLC was used to determine and analyze the peaks change of chemical components of single and co-decoction.The determination of Fructus Aurantii Immaturus and Radix Paeoniae Alba was performed on Syncronis-C18(4.6 mm×250 mm

5 μm) column with mobile phase consisted of acetonitrile-0.3% phosphoric-water at detection wavelength of 230 nm. Result: Nineteen peaks were selected as the fingerprint peaks.It was found that eight ingredients were increased and nine were decreased.This indicated that some changed more in all chemical components of co-decoction than single decoction. Conclusion: The compatibility of traditional Chinese medicine is not the simple adding of single herbs

but it includes some scientific base.

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