Objective:To optimize extraction technology of Baiqing gel. Method: With the content of paeonol as index

distillation extraction technology of Cynanchum paniculatum was investigated by single factor test;With the content of matrine

berberine hydrochloride and extract yield as comprehensive index

soaking time

the amount of water reflux times and time were chosen as factors

extraction technology of Baiqing gel was optimized by orthogonal test. Result: Distillate was collected with 10 times the amount of C. paniculatum

dregs(after distillation)

Phellodendron chinense

Sophora flavescens and other herbal pieces were extracted 3 times with 10 times the amount of water

1.5 h each time. Conclusion: This optimized technology was rational and stable with high extraction rate.