Objective: To study the effects of Jiangzhi Ⅱ Preparation on experimental hyperlipemia and atherogensis in rabbits. Method: The hyperlipemia and atherosclerosis model in rabbits was established by feeding high-fat diet. All animals were randomly divided into normal group

model group

simvastatin group

Jiangzhi Ⅱ high

middle and low dose groups (4.6

2.3

1.2 g·kg-1).After eight weeks of treatment

the content of total cholesterol(TC)

triglyceride(TG)

low density lipoprotein(LDL)

high density lipoprotein(HDL)

nitric oxide(NO) and endothelin (ET-1) in serum were determined. The extent of aortic atherosclerosis was observed and the pathological examination was done. Result: In the Jiangzhi Ⅱ treatment groups

the concentration of TC

TG

LDL

ET-1 in serum was decreased markedly

the concentration of HDL and NO was increased remarkably

the extent of aortic atherosclerosis and the atherosclerotic lesion were lightened obviously. Conclusion: Jiangzhi Ⅱ Preparation can effectively decrease the serum lipids and prevent the formation of atherosclerosis.