Objective:To develop an ultra performance liquid chromatography (UPLC) method for fingerprints of Jinlida granule. Method: The Waters Acquity UPLC BEH C18(2.1 mm×100 mm

1.7 μm) column was used. Acetonitrile and water containing 0.1% phosphoric acid were used as mobile phase with gradient elution. The detection wavelength was set at 203 nm. Flow rate was set at 0.3 mL·min-1 and column temperature was maintained at 40℃. Result: UPLC fingerprint was established with 50 common peaks

nine of 50 common peaks were identified

and the similar degrees of the UPLC fingerprints of Jinlida granule from 10 batches were between 0.991 and 1.000. Conclusion: The method of fingerprints has acceptable precision

reproducibility and stability

which can be used as a new means for the quality control of Jinlida granule.