Objective:To study the effect of Jiawei Sijun Guben Decoction with iressa on human non small cell lung cancer cell A549 xenograft model. Method: Subcutaneous A549 xenograft nudemice were divided into 4 groups randomly: control group (treated with glucose solution)

Western medicine treatmen(WMT) group (Iressa

100 mg·kg-1·d-1)

Chinese medicine treatment(CMT) group (Jiawei Sijun Guben decoction

0.10 g·kg-1·d-1) and Combined treatment(CT) group (Jiawei Sijun Guben decoction+Iressa). Tumor growth and life quality of tumor-bearing nude mice were observed. Western blotting and RT-PCR were used to detect the mRNA and protein expression of EGFR. Result: The tumor volumes of WMT

CMT and CT groups decreased greatly compared with control group

the inhibitory rate of tumor of was 55.75%

35.22% and 82.3% respectively (P<0.01). And the significant difference of tumor volumes in CT group was also showed compared with WMT and CMT group respectively (P<0.01). Life quality(amount of exercise

diet and body weight) of CT group was better than that of WMT group. EFGR protein and mRNA expression in tumor tissue of CT group were significantly lower than those of other groups. Conclusion: Jiawei Sijun Guben decoction plus Iressa therapy could inhibit tumor growth more effectively

which led to better treatment effect instead of using Iressa treatment alone. Jiawei Sijun Guben decoction therapy could greatly improve life quality of tumor-bearing nude mice during the treatment.