Objective: To study on molding process of traditional Chinese medicine(TCM) semi-extract film-coated tablet by taking Guanxinping tablet as model. Method: Prescription design and granulating of Guanxinping tablet was investigated by single factor test;With coating operation time and qualification rate of coating appearance as comprehensive evaluation index

orthogonal test was used to optimize film coating process parameters of Guanxinping tablet

and hygroscopicity study of semi-finished and finished products was used. Result: Fluidized bed granulation prescription of Guanxinping tablet was:dry extract powder mixed with 1.5%-2% tiny powder silica gel

with 1.9 times the amount of 60% ethanol as wetting agent;technology conditions were as follows:atomizing pressure 0.10-0.12 MPa

materials temperature 51-53℃

inlet air temperature 85-90℃

fan flow 120-140 M3· h-1

speed of feed liquid pump 10-15-20-26 r· min-1.Optimum film coating technology parameters were:the concentration of coating solution 16%

main engine speed 6-8 r· min-1

chip bed temperature 45-50℃.Optimal moisture content was 7.0%-9.0%

pressure of tableting machine 0.4-0.6 MPa. Mathematical equation of moisture rate with change of relative humidity was fitted Logistic model

relative humidity of operating environment should be controlled to <62%. Conclusion: Optimized molding technology was stable and feasible

it could be extended to large-scale production of Guanxinping tablet

this study could provide experimental basis for industrial production of TCM semi-extract film-coated tablet.