丹参滴注液与头孢西丁钠的配伍稳定性研究

张洪峰; 陈晨; 刘燕娟; 魏亚超; 李倩; 王乐; 李慧

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丹参滴注液与头孢西丁钠的配伍稳定性研究

更新时间：2024-01-04

- 丹参滴注液与头孢西丁钠的配伍稳定性研究
- Compatible Stability Studies on Danshen Dripping Solution and Cefoxintin Sodium for Injection
- 中国实验方剂学杂志 2012年18卷第23期页码：120-122
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- 纸质出版日期：2012
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张洪峰, 陈晨, 刘燕娟, 等. 丹参滴注液与头孢西丁钠的配伍稳定性研究[J]. 中国实验方剂学杂志, 2012,18(23):120-122.

ZHANG Hong-feng, CHEN Chen, LIU Yan-juan, et al. Compatible Stability Studies on Danshen Dripping Solution and Cefoxintin Sodium for Injection[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 120-122.
张洪峰, 陈晨, 刘燕娟, 等. 丹参滴注液与头孢西丁钠的配伍稳定性研究[J]. 中国实验方剂学杂志, 2012,18(23):120-122. DOI：

ZHANG Hong-feng, CHEN Chen, LIU Yan-juan, et al. Compatible Stability Studies on Danshen Dripping Solution and Cefoxintin Sodium for Injection[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 120-122. DOI：

摘要

目的: 研究丹参滴注液与头孢西丁钠的配伍稳定性。方法: 在模拟临床用药浓度条件下

考察丹参滴注液与头孢西丁钠配伍后溶液的外观、pH、不溶性微粒的变化

采用高效液相色谱法测定配伍后4 h内丹参素钠、原儿茶醛和头孢西丁的含量。结果: 4 h内配伍液的外观、pH无明显改变。随着时间的延长

不溶性微粒数增多

三者的含量均逐渐降低。结论: 丹参滴注液与头孢西丁钠配伍后4 h内不稳定

不建议配伍使用。

Abstract

Objective: To investigate the compatible stability of danshen dripping solution and cefoxintin sodium. Method: The content of sodium danshensu

protocatechualdehyde and cefoxintin were determined after compatibility of danshen dripping solution and cefoxintin sodium within 4 hours by HPLC

and the changes of solution color

pH value and insoluble particles were observed in the simulation conditions of clinical concentration. Result: The solution color and pH value showed no obvious changes. The number of insoluble particles was increased and the content of sodium danshensu

protocatechualdehyde and cefoxintin were reduced with the extending of compatible time. Conclusion: The solution was unstable after compatibility of danshen dripping solution and cefoxintin sodium within 4 hours

therefore

not suggesting to compatibility use.

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