二次回归正交旋转组合设计优化白芷香豆素磷脂复合物的制备工艺

董自亮; 傅超美; 徐瑞超; 高飞; 秦郁文; 黄静; 秦少容

您当前的位置：

首页 >

文章列表页 >

二次回归正交旋转组合设计优化白芷香豆素磷脂复合物的制备工艺

更新时间：2024-01-04

- 二次回归正交旋转组合设计优化白芷香豆素磷脂复合物的制备工艺
- Optimization of Preparation Technology for Coumarin from Phospholipid Complex by Quadratic Regression Rotation-orthogonal Combination Design
- 中国实验方剂学杂志 2013年19卷第6期页码：53-56
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
移动端阅览
董自亮, 傅超美, 徐瑞超, 等. 二次回归正交旋转组合设计优化白芷香豆素磷脂复合物的制备工艺[J]. 中国实验方剂学杂志, 2013,19(6):53-56.

DONG Zi-liang, FU Chao-mei, XU Rui-chao, et al. Optimization of Preparation Technology for Coumarin from Phospholipid Complex by Quadratic Regression Rotation-orthogonal Combination Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 53-56.
董自亮, 傅超美, 徐瑞超, 等. 二次回归正交旋转组合设计优化白芷香豆素磷脂复合物的制备工艺[J]. 中国实验方剂学杂志, 2013,19(6):53-56. DOI：

DONG Zi-liang, FU Chao-mei, XU Rui-chao, et al. Optimization of Preparation Technology for Coumarin from Phospholipid Complex by Quadratic Regression Rotation-orthogonal Combination Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 53-56. DOI：

摘要

目的: 优选白芷香豆素磷脂复合物的制备工艺。方法: 采用四因素二次回归正交旋转组合设计方法

以复合率为指标

选取投料比、白芷香豆素质量浓度、反应温度、反应时间为考察因素

优化白芷香豆素磷脂复合物的制备工艺。结果: 最佳制备工艺为以四氢呋喃为反应溶剂

白芷香豆素与磷脂投料比例1:3

药物质量浓度2 g·L-1

反应温度50 ℃

反应时间101 min

复合物结合率达98.58%。结论: 该优选的制备工艺稳定可行

为白芷香豆素新制剂的进一步研究提供参考。

Abstract

Objective: To optimize preparation technology of coumarin from Angelica dahurica phospholipid complex. Method: With recombination rate as index

feeding ratio

the concentration of coumarin from A.dahurica

reaction time and temperature were selected as factors

preparation technology of coumarin from A.dahurica phospholipid complex was optimized by four factors quadratic regression orthogonal rotation combination design method. Result: Optimum preparation technology was as following:with tetrahydrofyran as reaction solvent

proportion of coumarin from A.dahurica to phospholipid 1:3

the concentration of coumarin 2 g·L-1

reaction temperature 50 ℃

reaction time 101 min.Recombination rate of the complex was up to 98.58%. Conclusion: This optimized preparation technology was stable and feasible

it could provide reference for further study on new preparations of coumarin from A.dahurica.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

灯盏花乙素-磷脂复合物纳米乳的体内外评价及其改善脂多糖诱导血管内皮损伤的活性分析

补阳还五汤方中红花黄芪配伍总黄酮的制备工艺

芍石护睛胶囊的制备工艺研究

滑肠通便片的制备、质量控制与临床疗效探讨