Objective:To observe the treatment of Deduhonghua-7 Powder on rat with carbon tetrachloride(CCl4) induced hepatic fibrosis. Method: Rats were randomly divided into normal control group

model group

Colchicine group and Deduhonghua-7 powder group. Except the normal control group

other groups were caused hepatic fibrosis by ip 30% CCl4 solution of olive oil. Modeling the same time

the rats in Deduhonghua-7 powder group and Colchicine group were ig 0.62 g·kg-1 and 0.4 mg·kg-1 each day of Deduhonghua-7 powder and Colchine respectively

continued for 7 days. Liver indexes

liver function

fibrosis four projects were observed

pathological changes in liver tissues were evaluated by HE

Gomori

Masson stainings. Result: Comparing with normal control group

aspartate transaminase(AST)

alanine transpeptidase(ALT)

alkaline phosphatase(ALP)

total protein(TP)

total bilirubin(TBIL)

liver indexes

fibrosis four projects of serum and liver tissues homogenates were significantly increased

albumin(Alb)

and bodyweight were decreased in the model group (P<0.05). Comparing with model group

in the Deduhonghua-7 Powder group

AST

ALT

ALP

liver indexes

liver tissues homogenates Hyp

serum and liver tissues fibrosis four projects were significantly decreased

Alb was increased; and in the Colchine group

ALT

AST

ALP

BIL were decreased

liver tissues hyaluronic acid(HA) was increased

IV was decreased (P<0.05). Comparing with Colchine group

Deduhonghua-7 Powder group’s Alb was increased

serum HA

LN contents were decreased

liver tissues HA

LN

IV-C

Hyp contents were decreased (P<0.05). Conclusion: Deduhonghua-7 Powder showed good effect on reducing enzyme

protecting liver and anti-fibrosis for liver.