常春藤皂苷元对胃癌细胞MGC-803增殖、黏附、侵袭和迁移能力的影响

刘包欣子; 王瑞平; 邹玺; 周锦勇

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常春藤皂苷元对胃癌细胞MGC-803增殖、黏附、侵袭和迁移能力的影响

更新时间：2024-01-04

- 常春藤皂苷元对胃癌细胞MGC-803增殖、黏附、侵袭和迁移能力的影响
- Effect of Hederagenin on Biological Behaviors Including Proliferation,Adhesion, Invasion and Migration Capabilities of Human Gastric Cancer Cell Line
- 中国实验方剂学杂志 2013年19卷第4期页码：212-215
- 作者机构：
- 作者简介：
- 基金信息：
  
  江苏省高校优势学科建设工程项目;江苏省中医药领军人才项目(LJ200908)
- DOI：
  中图分类号：
- 纸质出版日期：2013
- 稿件说明：
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刘包欣子, 王瑞平, 邹玺, 等. 常春藤皂苷元对胃癌细胞MGC-803增殖、黏附、侵袭和迁移能力的影响[J]. 中国实验方剂学杂志, 2013,19(4):212-215.

LIUBAO Xin-zi, WANG Rui-ping, ZOU Xi, et al. Effect of Hederagenin on Biological Behaviors Including Proliferation,Adhesion, Invasion and Migration Capabilities of Human Gastric Cancer Cell Line[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 212-215.
刘包欣子, 王瑞平, 邹玺, 等. 常春藤皂苷元对胃癌细胞MGC-803增殖、黏附、侵袭和迁移能力的影响[J]. 中国实验方剂学杂志, 2013,19(4):212-215. DOI：

LIUBAO Xin-zi, WANG Rui-ping, ZOU Xi, et al. Effect of Hederagenin on Biological Behaviors Including Proliferation,Adhesion, Invasion and Migration Capabilities of Human Gastric Cancer Cell Line[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 212-215. DOI：

摘要

目的: 探讨常春藤皂苷元对胃癌细胞MGC-803细胞的生长、黏附、侵袭和迁移能力的影响。方法: 采用MTT法、细胞黏附实验、Transwell小室侵袭实验、划痕实验检测对人胃癌细胞MGC-803的增殖、黏附、侵袭、迁移能力的影响。结果: ①常春藤皂苷元有抑制人胃癌细胞MGC-803增殖的作用

与对照组比较

随着药物质量浓度的增大

其对细胞的抑制率也明显增大(P<0.01)

呈现质量浓度依赖性。②常春藤皂苷元作用人胃癌细胞MGC-803后

细胞的黏附能力明显降低(P<0.01)

随着质量浓度的增加和时间的推移

呈现抑制率递增的结果。③常春藤皂苷元作用人胃癌细胞MGC-803后

侵袭的细胞数较对照组明显减少(P<0.01)

质量浓度越高

侵袭的数量越少。④常春藤皂苷元作用人胃癌细胞MGC-803后

细胞愈合的程度有明显的分组差别

质量浓度越高

愈合度越差

表明迁移能力受到很大影响。结论: 常春藤皂苷元对人胃癌细胞MGC-803的增殖具有抑制作用;常春藤皂苷元能抑制人胃癌细胞MGC-803的黏附能力、侵袭能力和迁移能力。

Abstract

Objective: This study was designed to explore:the effect of hederagenin on the biological behaviors including proliferation

adhesion

invasion and migration capabilities of human gastric cancer cell line MGC-803 in vitro. Method: Using MTT

adhesion experiment

transwell room

wooding healing to observe the effect of hederagenin on the biological behaviors including proliferation

adhesion

invasion and migration capabilities. Result: ①Hederagnin significantly inhibited the proliferation of MGC-803 cells. (P<0.01)

the result showed that inhibition ratio increase with the increasing of the concentration of concentration and the passage of time. ② Hederagnin significantly decreased the adhesion capability of MGC-803 cells (P<0.01)

along with the increasing of the concentration and the passage of time

present the results of inhibition rate increasing. ③Hederagnin roled in human gastinc cancer cells MGC-803 so that the cell invasion number is significantly reduced (P<0.01)

the higher concentration

the less the number of cell invasion. ④After hederagnin roled in human gastric cancer cells MGC-803

cell healing degree have obvious group difference

the higher concentration

the worse of degree of healing

which showed that migration ability greatly affected. Conclusion: Hederagnin can inhibite the proliferation of human gastric cell line MGC-803 and supresse the adhesion

invasion and migration capability of MGC-803 cells.

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