Objective: To observe the therapeutic effects of astragalus saponin on rats with atrophic gastritis (CAG)

and on myeloid differentiation factor 88(MyD88)

Toll-like receptor 4(TLR4) receptor. Method: The rat model of atrophic gastritis was established with synthesis method.Then saline

astragalus saponin(14.93 mg·kg-1) and sucralfate(360 mg·kg-1)were given orally after the modeling rats were sacrificed after 10 weeks and 15 weeks

and whole stomach was collected to observe whether there were intestinal metaplasia

pseudo-pyloric metaplasia

atypical hyperplasia under the microscope

the expression of MyD88 and TLR4 was detected. Result: Astragalus saponin had a therapeutic effect on rats with atrophic gastritis

the occurrence of intestinal metaplasia

pseudo-pyloric metaplasia

atypical hyperplasia significantly reduced

at the same time

the expression of TLR4 and MyD88 decreased significantly compared with blank group and sucralfate group

higher expression of superoxide dismutase(SOD) activity in astragalus saponin group was found. Conclusion: Astragalus saponin can prevent the activation of MyD88

TLR4 receptors and improve the activity of SOD

it has a therapeutic effect on atrophic gastritis.