Objective: To study the therapeutic effect of mecobalamine Iadacum of Zusanli combined with Buqi Huoxie Tongbi soup (BTS) on patients with diabetic peripheral neuropathy(DPN). Method: Seventy-eight cases of DPN were divided randomly into two groups. Treatment group with 40 cases was orally given BTS plus mecobalamine Iadacum of Zusanli and control group with 38 cases was orally given BTS plus mecobalamine gluteal region intramscular injection; the clinical symptom

motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV) and other indicators were observed; the course of treatment was 2 weeks. Result: The total effective rate was 97.5% in treatment group and 84.21% in control group(P<0.05)

respectively; MNCV and SNCV improved better in treatment group than in control group(P<0.01 or P<0.05); the integral of clinical symptom was less in treatment group than in control group(P<0.01) after two-week treatment. Conclusion: Mecobalamine Iadacum of Zusanli combined with BTS in patients with DPN is effective in relieving the clinical symptoms and improving MNCV and SNCV.