Objective:To investigate the anti-liver fibrosis effect of water extract of Cudrania cochin\|chinensis in rats. Method: One hundred and thirty Sprague-Dauley(SD) rats were randomly divided into control group

model group

postitive control group and three differrent doses(4.57 g·kg-1

3.05 g·kg-1

1.52 g·kg-1) of water extract of C. cochinchinensis treatment group. Liver fibrosis rat model was induced by carbon tetrachloride(CCl4). Except control group

other groups were given drugs when being given carbon tetrachloride. Ending the study at the eighth week

liver function(alanine amino transferase(ALT)

aspartate amino transferase(AST)

total protein(TP)

albumin(Alb)

globulin(Glob))

serum concentrations of nitric oxide(NO)

malondialdehyde(MDA)

alkaline phosphatase(AKP)

hyaluronic acid(HA)

laminin(LN)

procollagen-III(PCⅢ) and collagen-IV(CⅣ) were measured.The concentrations of hydroxyproline(HYP) in liver hydrolysate were measured too.Moreover

pathological examination on liver tissue was made. Result: Serum concentrations of ALT

AST

AKP

HA

LN

CⅣ and concentration of HYP in liver hydrolysate was significantly higher in liver fibrosis model group

however

the concentrations of TP

Alb

SOD were significantly lower in model group. Compared with model group

the serum concentrations of ALT

AST

PCⅢ

HA and concentration of HYP in liver hydrolysate were significantly decreased in water extract of C. cochinchinensis treatment groups and the serum concentrations of SOD

TP

Alb were significantly increased in water extract of C. cochinchinensis treatment groups. Pathological result showed that the liver fibrosis in water extract of C. cochinchinensis groups was significant improved. Conclusion: Water extract of C. cochinchinensis has significant therapeutic effect on liver fibrosis induced by carbon tetrachloride in rats.