Objective:To observe the clinical efficacy of Fuzheng Xiao'ai decoction (FX) treatment for esophageal cancer after chemotherapy. Method: Seventy-six cases of esophageal cancer after surgery were randomly divided into treatment and control groups. Control group of 37 cases was treated with 5-fluorouracil (5-FU)

cisplatin (DDP)

and with the necessary symptomatic treatment. On the treatment basis of the control group

the treatment group (n=39) was postoperatively started FX for 12 weeks. The adverse reactions

KPS score

and serum immunoglobulin were observed. Result: The incidences of adverse reactions in treatment group were lower than those in the control group (P<0.05

P<0.01) including the delayed gastric emptying

diarrhea

loss of appetite and the weight loss> 5%. After 1 month of treatment

at the end of chemotherapy and two weeks after the end of chemotherapy

KPS score were higher in the treatment group (P<0.01). In the treatment group

IgG

IgA

and IgM levels were higher than those in the controls by the end of the treatment (P<0.05

P<0.01). However

the total effective rates in the treatment group and the control group were 79.48% and 70.27% accordingly. Conclusion: FX can reduce the adverse reactions caused by esophageal cancer surgery and chemotherapy to improve patients' quality of life

improve immune function.