Objective: To investigate the influence of Xueshuan Xinmaining capsule in patients with coronary heart disease and impact on interleukin (IL-6)

tumor necrosis factor (TNF-α) and high-sensitivity C-reactive protein (hs-CRP). Method: Sixty-five patients with coronary heart disease were randomly divided into treatment group of 33 cases and control group of 32 cases. Both groups were given a conventional treatment

the treatment group was additionally given Xueshuan Xinmaining capsule

4 grain tid for 8 weeks. The level of IL-6

TNF-α

hs-CRP

ECG and the count of angina pectoris were observed. Result: For angina pectoris

the total effective rate of treatment group was 90.9%

better than the control group of 56.3% (P<0.01). The electrocardiogram total effective rate in treatment group was 84.8%

better than the control group of 56.3% (P<0.01). After treatment

the serum IL-6

TNF-α and hs-CRP in treatment group were significantly lower than those in the control group (P<0.01). Conclusion: Xueshuan Xinmaining capsule can reduce the count angina pectoris in patients

improve patients' ECG and reduce IL-6

TNF-α and hs-CRP level. Its mechanism may be related to its anti-inflammatory action.