Objective: To observe the clinical curative effect of Chinese medicine on patents Jianpi Xiaotang granule in treating prediabetic state and the effects on inflmation factors interleukin-6(IL-6)

tumor necrosis factor-α(TNF-α) and hypersensitive 3C-reactive protein(HsCRP). Method: One hundred and serenteen cases with diabetes mellitus(DM) was divided into treatment group of 59 cases and control group of 58 cases. Both groups received health education and life intervention treatment. The treatment group received Jianpi Xiaotang granule and acarbose tablets and the control group was given the acarbose tablets. The treatment courselasted six months and the change of the fasting plasma glucose(FPG) and 2 hour plasma glucose(2 hPG)

hemoglobin A1c(HbA1c) and IL-6

TNF-α and HsCRP was observed. Result: The inflamtion factor indexes were reducd (P<0.05). Compared with the control group

the TNF-α

HsCRP level was reduced significantly(P<0.01).The level FPG

2 hPG

HbA1c was reduced significantly(P<0.05)

compared with FPG

HbAlc was reduced more significantly(P<0.01). Conclusion: Both Jianpi Xiaotang granule and acarbose can improve the level of FPG

2 hPG

HbA1c and the curative effect of Jianpi Xiaotang granule is even more satisfied.The reinforcing spleen and hypoglycemic granule significantly reduce the level of infalmation factor.