结合化学与药效学指标优选参芪麝蓉丸的纯化工艺

周永全; 刘书芬; 张宁; 王拥军; 杜思邈

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结合化学与药效学指标优选参芪麝蓉丸的纯化工艺

更新时间：2024-01-04

- 结合化学与药效学指标优选参芪麝蓉丸的纯化工艺
- Optimization of Purification Technology for Shenqi Sherong Pills by Chemical and Pharmacodynamic Indicators
- 中国实验方剂学杂志 2013年19卷第6期页码：36-39
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- 基金信息：
  
  上海市科学技术委员会项目(09dZ1977200)
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- 纸质出版日期：2013
- 稿件说明：
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周永全, 刘书芬, 张宁, 等. 结合化学与药效学指标优选参芪麝蓉丸的纯化工艺[J]. 中国实验方剂学杂志, 2013,19(6):36-39.

ZHOU Yong-quan, LIU Shu-fen, ZHANG Ning, et al. Optimization of Purification Technology for Shenqi Sherong Pills by Chemical and Pharmacodynamic Indicators[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 36-39.
周永全, 刘书芬, 张宁, 等. 结合化学与药效学指标优选参芪麝蓉丸的纯化工艺[J]. 中国实验方剂学杂志, 2013,19(6):36-39. DOI：

ZHOU Yong-quan, LIU Shu-fen, ZHANG Ning, et al. Optimization of Purification Technology for Shenqi Sherong Pills by Chemical and Pharmacodynamic Indicators[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 36-39. DOI：

摘要

目的: 优选参芪麝蓉方的纯化工艺条件。方法: 以黄芪甲苷含量为化学指标

足趾肿胀率、脊髓损伤大鼠的BBB评分及病理切片为药效学指标

通过大鼠足趾肿胀试验及脊髓损伤大鼠相关试验确定参芪麝蓉方水提液的纯化工艺。结果: 优化的纯化工艺为水提液浓缩后加乙醇至含醇量为60%。结论: 化学指标与药效学指标筛选参芪麝蓉方水提液的纯化条件具有一致性

为保证参芪麝蓉方的质量提供实验依据。

Abstract

Objective: To optimize purification technology conditions of Shenqi Sherong prescription. Method: With the content of astragaloside Ⅳ as chemical index

while BBB score and pathological section of rats after spinal cord injuried and toe swelling rate as pharmacodynamic indexes

purification technology of water extract from Shenqi Sherong prescription was optimized according to the above mentioned indexes. Result: Optimized purification conditions was as following:after concentrated

water extract was added alcohol until the alcohol content of 60%. Conclusion: Purification technologies for water extract of Shenqi Sherong prescription had consistency by screening chemical index and pharmacodynamics indexes

it could provide experimental basis for guaranteeing quality of Shenqi Sherong prescription.

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