Objective: Study the effects and mechanism of Banxia Xiexin decoction on gastric cancer. Method: Banxia Xiexin decoction was divided into Pungent openning(dried ginger

pinellia ternate)group

Bitter Descending(coptis chinensis

scutellaria) group and Invigoration(glycyrrhiza

ginseng) group by its different nature and flavor. 1×104cells/wells were planted at 96 wells plate

drug concentrations were 4

2

0.5

0.125 g·L-1

cell proliferation was detected by MTT method. 1×105 cells/wells were planted in 6 wells plate. The high and low concentration of whole Party and Bitter Descending drugs was respectively 0.5

0.125 g·L-1. The high and low concentration of Pungent openning and invigoration was respectively 4

2 g·L-1. Effect of Banxia Xiexin decoction and compositions on gastric cancer SGC-7901 cells proliferation

cell cycle and apoptosis ratio were detected and compared with known positive drug 5-fluorouracil (5-FU). Result: Banxia Xiexin decoction group

Bitter Descending group and Pungent opening group could inhibit the proliferation of SGC-7901 cell

the IC50 values of its were 1.645

1.446

3.867 g·L-1 respectively

and increased SGC-7901 cells in S phase and G0-G1 phase percentage with promoting apoptosis in dose-dependent manner

but invigoration group had no such effect. Conclusion: Banxia Xiexin decoction and its compositions can inhibit the proliferation of SGC-7901 cell

Bitter Descending is strongest and Invigoration group is the weakest

which may be related to blocking of cells to G1/S phase and inducing cell apoptosis