Objective:To optimize forming prescription of lutein microcapsule dispersible tablet. Method: With appearance

suspension

disintegration time and dissolution as comprehensive evaluation indexes

type and amount of filler and lubricant

type of disintegrating agent

wetting agent and swelling accessories were determined by single factor test

forming technology prescription of lutein microcapsule dispersible tablet was optimized by orthogonal test. Result: Optimum forming prescription was:with consisted of 25%CMS-Na and PVPP(1∶1) as disintegrating agent

6% HPC as swelling accessory

and 70% ethanol as wetting agent.These prepared dispersible tablet could disintegrate completely within 80 s

dissolution was more than 90% within ten min. Conclusion: This optimized formulation was rational and stable with smooth appearance

rapid disintegration

high dissolution and good development prospect.