Objective:To observe the clinical efficacy of Zishen-Shugan-Ningxin prescription combind with acupuncture to treat menopausal depression

in order to provide more safe and effective method for the treatment of menopausal depression. Method: Choosing 96 patients with depression from February 2010 to June 2011 in our hospital as the samples and divided them into three groups

they were given the Zishen-Shugan-Ningxin

acupuncture

and combination treatment. Then using the Hamilton Depression Rating Scale (HAMD) and menopausal index (KMI) scale to evaluate the therapeutic effect of the three groups. Result: After the treatment of 2

4

8 week

the difference of HAMD score were significant

prescription + acupuncture group was significantly lower than the other two groups; but there were no significance between simple prescription group and acupuncture group (81.25% vs 78.13% after treatment. (χ2=0.097

P= 0.527)

while the total effective rate of prescription + acupuncture treatment was 96.88 percent

what were significant with prescription group and acupuncture group

respectively (χ2=4.010

P= 0.046

χ2=5.143

P=0.046). Conclusion: Using Zishen-Shugan-Ningxin prescription with acupuncture to treat menopausal depression were significantly of the effect

not only can effectively prevent a variety of side effects of western medicine

but the results are stable and less recurrence

the patient can easy to accept this treatment

and it is indeed a safe and effective treatment.