Objective:To study the anti-inflammatory and antibacterial effects of Gegen Qinlian decoction prepared by different technology. Method: The swelling of ear induced by xylene in mice was employed to evaluate the anti-inflammatory effects of Gegen Qinlian decoction prepared by different technology. Additionally

the model of bacteriostasis in vitro by the serum with drug was used to examine the antibacterial activities of those. Result: Compared with mixed decoction and separated decoction

extract of active ingredients (1.95 g·kg-1) strongly inhibited swelling of ear in mice(P<0.01). The serum with extract of active ingredients significantly inhibited 10 kinds of strains such as Escherichia coli

Staphylococcus aureus and Salmonella typhi

etc. (P<0.01). Conclusion: Extract of active ingredients can exert significant inhibitory action against inflammation caused by chemical agents

and the serum with extract of active ingredients also has strong antibacterial activity.