Objective:Taking Gegen Qinlian decoction as study object

To study comprehensively on relationship between parameters which influence quality of decoction (such as water amount

decocting time

et al.) and dissolution of main ingredients

and obtain optimum decocting process of Gegen Qinlian decoction. Method: Decocting time had 20

35

50

65

80 min;the amount of water were 6

9

12

15

18 times;decocting times of one time;Decocting process was determined by permutation and combination of the above parameters with comprehensive experimental method.Each process of modified Gegen Qinlian decoction took one formula to decoct three times.The content of main ingredients were determined by HPLC

and influence of different decocting processes on dissolution was compared. Result: ①Under the same decocting time and decocting times

dissolution of main ingredients showed a upward trend with increasing of water amount

significant changeed at 9 times the amount of water.②Under the same water amount and decocting times

while different decocting time

dissolution of main ingredients showed a upward trend with extension of decocting time

obvious change point at 50 min. Conclusion: The minimum amount of water for Gegen Qinlian decoction was 9 times

decocting time was 50 min.