Objective: To investigate the clinical efficacy Longdan Xiegan decoction (LXD) for treating herpes zoster (HZ) in patients with middle and severe depressive emotion. Method: Seventy-four herpes zoster patients with middle and severe depressive emotion were randomly divided into observation group and the control group (n=37 each). The control group was given oral famciclovir (0.25 g

bid) antiviral treatment for 7 d

combined with flupentixol 2 tables bid for 14 d

the observation group was given additional treatment on the basis of the control group with LXD modified according to the different syndromes. The treatment lasted 2 weeks. HZ efficacy

and the treatment of depression

pain and sleep before and after treatment were observed and assessed. Result: The two groups showed efficiency of 94.5% and 64.9% accordingly; the observation group was significantly higher than that in the control group (P<0.01). The depression

pain and sleep scores of the observation group were improved and better than those in the control group (P<0.01). No significant adverse reactions in the two groups in the medication process. Conclusion: Treatment of integrated traditional Chinese and western medicine for herpes zoster with middle and severe depressive emotion is effective.