Objective: To investigate the effect of flavonoids extracted from Lysimachia Hristinae Hance on renal oxalate calcium(CaOx) stone formation in rats. Method: The rat model of renal calcium oxalate stones formation was induced by administering 1% ethylene glycol(EG) for 9 weeks

then these rats were fed with 100

200

400 mg·kg-1of flavonoids extracted from Lysimachia Hristinae Hance respectively for 6 weeks. The concentration and the 24 h content of oxalic acid in urine was determined by paired ion high performance liquid chromatography

the serum urea nitrogen(BUN)

Cr

Ca2+

P3+

K+

and Na+ content in serum were determined by automatic biochemical analyzer

the Ca2+ and Mg2+ content in kidney tissues and urine was determined by atomic absorption spectrometry

the distribution of crystals in renal tubular and the renal tubular distension were observed under microscope. Result: In the rats administered with different doses of flavonoids

renal tissue calcium content

urinary calcium excretion and crystals deposition in renal tissue and tubular ectasia were significantly lower than those of the mode;group of stone formation (P<0.05). However

there were no significant differences between the two groups in the concentrations of Ox and the 24 h content of Ox in rats. Conclusion: The flavonoids can inhibit experimental kidney calcium oxalate crystal formation in hyperoxaluria rat. The reason may be related to the metabolism of calcium was regulated by the flavonoids.