Objective:To observe the curative effect of Huoxue Huatan decoction on experimental model of nonalcoholic fatty liver in rats. Method: Experimental animals model of nonalcoholic fatty liver in rats were established by feed of fatty food for 6 weeks

then experimental animals were divided into 6 groups which were treated with Huoxue Huatan decoction and Rosiglitazone respectively for another 6 weeks. Biochemical indexes and liver tissue of rats were tested after treatment. Result: Huoxue Huatan decoction could reduce the level of alanine aminotransferase (ALT)

which was much better than Rosiglitazone[(50.7±12.2)

(41.3±9.9)

(66.3±29.1)

(56.9±14.2)

(71.3±25.9)U·L-1

P<0.05]

and Huoxue Huatan decoction can also reduce the level of total cholesterol (TC) [(1.3±0.3)

(1.5±0.4)

(2.6±1.1) mmol·L-1

P<0.01]and triglyceride (TG) [(0.3±0.2)

(0.4±0.2)

(0.5±0.2) mmol·L-1

P<0.05]

while the high dose group of Huoxue Huatan decoction could reduce glucose (Glu) obviously[(9.0±1.3)(11.4±2.0) mmol·L-1

P<0.01] and improve the hemorheology indexes(P<0.05)

reduce the level of FFA[(1.77±0.29)

(1.66±0.44)

(2.04±0.27) μmol·mg-1

P<0.05] and TG[(0.73±0.16)

(0.81±0.22)

(0.57±0.11)

(1.06±0.33) mmol·mg-1

P<0.05] in liver. Conclusion: Huoxue Huatan decoction can improve pathological conditions of nonalcoholic fatty liver disease(NAFLD) model by adjusting metabolism of blood liquid and improving liver function.