Objective: To determine Qingrejiedu oral liquid by HPLC fingerprint of the 4 major effective component content in order to establish effective quality evaluation method. Method: The determination of HPLC fingerprint was established to analyze the quality of products sold in the market. The chromatographic conditions were as follows: Shim-Pack VP-ODS C18 HPLC column (4.6 mm×250 mm

5 μm); mobile phase methanol-0.1% phosphate gradient elution

detection wavelength of 227 nm. Result: The chromatographic parameters of HPLC fingerprints were better. 10 batches of fingerprint evaluation by similarity showed that there were larger differences between sold in Qingrejiedu oral liquids by different manufacturers. Conclusion: The method is simple

accurate with high sensitivity and repeatability

which can serve as a quality control method of Qingrejiedu oral liquid; there are significant differences between the varieties of preparation sold in.