Objective:To optimize matrix prescription of Jiangni cataplasma. Method: With adhesion

uniformity of appearance

spread property and follow as comprehensive evaluation indexes

proportion and dosage of adhesive

the amount of moisturizing agent and crosslinking agent were chosen as factors

adjuvant prescription and preparation technology parameters was optimized by L16(45) orthogonal test;With in vitro transdermal drug release ratio as index

type and amount of transdermal absorbent was optimized by single factor. Result: Optimal matrix formulation was:proportion of adhesives(sodium polyacrykate-CMC-Na 4∶3)

moisturizing agent(glycerol)

crosslinking agent(aluminum trichloride)

penetrating agent(azone-propylene 1∶1) to dry extract powder were 35∶100

160∶100

2∶100 and 30∶100

respectively. Conclusion: This optimized technology was stable and feasible

and it could provide experimental basis to define preparation technology parameter of Jiangni cataplasma.