Objective:To observe the effect of salvianolic acid B(Sal B) on the angiogenesis in ischemic myocardium of the rats with myocardial ischemia. Method: The left coronary of SD rats were blocked to make the models of acute myocardial ischemia. Sixty rats were randomized into model group

Sal B groups (1.6

3.2

6.4 mg·kg-1) and vascular endothelial cell growth factor(VEGF) group. A sham operation group was set up. Ten rats were included in each group. Two weeks after administration

HE staining was used to detect the myocardial infarct size; using kits to detect the contents of nitrogen oxide(NO)

NO synthase(NOS) and VEGF in myocardial tissue; immunohistochemical method was employed to detect microvessel counts(MVC) in ischemic myocardium. Result: The infarct size of myocardium in Sal B 3.2

6.4 mg·kg-1 groups (7.18±3.15)%

(5.74±2.02)% was lower than that in the model group(14.84±5.40); Sal B could increase the contents of NO

NOS and VEGF in myocardial tissue. The number of MVC in the marginal zone of myocardial infarct in Sal B 3.2

6.4 mg·kg-1 groups (28.6±5.86)

(30.20±5.07) was higher than that in the model group(15.60±4.62). Conclusion: Sal B may promote angiogenesis of ischemic myocardium in the rats with myocardial ischemia. Its mechanism might be related to promoting the contents of VEGF and NO.