Objective:To study influence of Sini powder on interleukin(IL )-6 and IL-13 in experimental ulcerative colitis (UC) rats. Method: Rats were divided into 5 groups

including the normal group

model group

Sini powder group

Chaishaozhi group and Chaishao group. The model was made with immunization that fresh rabbit colonic mucosa were made into antigen emulsion

and injected into the rat’s bilateral paws

groins and backs in 1st

10th

17th

24th day after modeling. Meanwhile

corresponding drugs were ig given from the 2nd day after modeling. The normal group and model group were gavaged with 10 mL·kg-1 distilled water; and Sini powder powder group with 1.75 g·kg-1 Sini powder solution; and Chaishaozhi group with Chaishaozhi 1.31 g·kg-1 Chaishaozhi solution; and Chaishao group with 0.88 g·kg-1 Chaishao solution. On the 29th day

we sacrificed the rats and drawn. Through detecting IL-6 and IL-13 levels of rat’s colon mucosal tissue and serum with ELISA. Result: IL-6 levels of model group(163.64±22.17)μg·L-1 higher than normal group(59.80±11.72)μg·L-1

P＜0.05

and IL-13 levels(78.64±12.66)μg·L-1 lower than normal(616.00±133.80)μg·L-1

P＜0.05.After feeding experimental herbal medicine

Sini powder can significantly reduce experimental rat’s IL-6 levels (73.00±9.92)μg·L-1(P＜0.05) increased IL-13 levels (264.89±128.05)μg·L-1(P＜0.05). After removing licorice

Chaishaozhi compatibility could only reduce the level of IL-6 (131.75±31.93)μg·L-1(P＜0.05)with no increased level of IL-13.While the compatibility of Chaishao could not only reduce the levels of IL-6

but reduce IL-13 content. Conclusion: The mechanism of Sini powder intervening experimental UC is related to the balance of cytokine network. The function of Sini power lies in influencing IL-6

IL-13

but the compatibility of Chaishao did not play a major role.