Objective: To investigate external Zhuangyang San combined with oral Zhenwei decoction in treating impotence patients. Method: Ninety-eight cases during 2009-2012 as the data source

were divided into the observation group and the control group. The therapeutic effect and life quality were compared between the two groups. Result: The total effective rate in the observation group was 95.82%

while was 73.47% in the control group

with significant difference between two groups (P<0.05). The IIEF-5 score

insert success rate and successful erection rate were better than those in the control group (P<0.01); HAMD score and HAMA score of the observation group were lower than those in the control group (P<0.01). Conclusion: External Zhuangyang San combined with oral Zhenwei decoction have good effect for treating impotence.