Objective: To evaluate the clinical effects of retention-enema of dragon's blood in treatment of ulcerative colitis(UC) applying the method of Meta-analysis. Method: A comprehensive data were colledted on dragon's blood or compound dragon's blood preparations treating ulcerative colitis.All literature were assessed via. The Cochrane collaboration's tool for assessing risk of bias and application of quality and GRADE system evidence were used for level classification and RevMan5.1.7.0 software was used to evaluate the results of the total effect of Meta-analysis and sensitivity analysis. Funnel-plot analysis was used to identify the publication bias. Result: Six reports were identified in this Meta-analysis. GRADE system for low level recommended classification

recommend intensity as the weak recommended in methodology. Meta-analysis results showed that retention-enema of dragon's blood versus sulfasalazine in the treatment of ulcerative colitis:RR=1.13

95%CI=[1.03

1.24]

z=2.67

P<0.05. The results of Meta analysis showed that treatment group is better than control group and differences were significant. Sensitivity analysis showed that the evaluation result was stable and funnel figure graphics was symmetric. Literature had better security. Conclusion: Retention-enema of dragon's blood in treament of ulcerative colitis has certain therapeutic effect.