SUN Lei, MA Xiao-lan, WU Yang, et al. Preparation and Dissolution Characteristics Investigation of Rutin Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 23-25.
SUN Lei, MA Xiao-lan, WU Yang, et al. Preparation and Dissolution Characteristics Investigation of Rutin Solid Dispersions[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 23-25.DOI:
Objective: To prepare rutin solid dispersions(RSD)
and compare influence of different carriers on in vitro dissolution of it. Method: RSD was prepared by solvent method and its in vitro dissolution was tested.Influence of different carriers on drug dissolution was evaluated.Differential scanning calorimetry (DSC) was used to examine presence state of rutin in carrier. Result: Types and amount of carriers had significant influence on rutin dissolution
PVPK30 was chosen as optimum carrier
DSC showed that rutin dispersed in PVPK30 with amorphous and microcrystalline. Conclusion: Rutin dissolution and dissolution rate of these prepared rutin-PVPK30 solid dispersions were significantly improved.