Objective: To investigate the joint effect of Guanxinning injection combined with Xueshuantong injection for treatment of unstable angina. Method: Eighty patients with unstable angina patients were randomly divided into two groups by order of admission. Forty patients was treated by conventional therapy based on puerarin injection 400-600 mg+5% glucose 250 mL gtt as the control group

and another 40 patients were treated by joint Guanxinning injection 20 mL 5% glucose 250 mL combined with Xueshuantong injection 120 mg+5% glucase 250 mL gtt on the basis of the conventional treatment as the observation group. The clinical course was lasted for two weeks. Before and after treatment

C-reactive protein (CRP)

hemorheological parameters

ECG and the outcome of treatment were observed and compared. Result: After treatment

compared with the control group

hemorheological parameters (hematocrit

whole blood viscosity

fibrinogen) and CRP were decreased more significantly (P<0.05). Angina symptoms were improved in the observation group and the total effective rate was 87.50%

while 65.00% in the control group. The difference was statistically significant (P<0.05). The ECG effective rate in the observation group was 75.00%

and 50.00% in the control group

with significant difference (P<0.05). Conclusion: The joint effect of Guanxinning injection combined with Xueshuantong injection for treatment of unstable angina can significantly improve hemorheological parameters and reduce CRP.