Objective:To optimize preparation technology of tanshinone solid dispersion dipping pills. Method: Independent variables were proportion of drugs and excipients

melting tempratrue

PEG4000-PEG6000

kind of solubilizer

with dissolution in 10 min of tanshinone was dependent variable

preparation technology of tanshinone solid dispersion was optimized by orthogonal design;Existential state of drugs in this solid dispersion was analyzed by DSC

X-ray and IR.At the same time

preparation technology parameters of tanshinone solid dispersion dripping pill was optimized. Result: Optimum preparation technology of solid dispersion was:proportion of drugs and pharmaceutic adjuvants 1∶5

melting tempratrue 70 ℃

PEG4000-PEG6000 1∶1

poloxamer as solubilizer;Though analysis of DSC

X-ray and IR

drugs were molecular state in tanshinone solid dispersion

prepared solid dispersion was filled-type solid solution;Optimum preparation technology of dripping pills was:1000cs dimethyl silicon oil as condensing agent

temperature 20 ℃

dropping distance 4 cm

dropping speed 30-40 d·min-1

the average cumulative dissolution of prepared dripping pill was 85%. Conclusion: Prepared tanshinone solid dispersion could significantly improve in vitro dissolution of tanshinone

this prepared tanshinone dripping pills could achieve requirements of immediate-release.