Process on drug delivery for brain targeting was summarized to provide basis for traditional Chinese mediline (TCM).Literatures about the development of brain-targeted preparation in recent years were reviewed and analyzed. This paper not only described the physiological structure characteristics of blood-brain-barrier

but also introduced some common methods for promoting drugs through the blood-brain-barrier.The paper also described the administration methods and new preparations(β-CD

prodrug

liposomes

nanoparticles

micro emulsion

in situ gel)to understand the advantages and feasibility of traditional Chinese medicine(TCM) nasal administration. Brain-targeted preparations of TCM had wide development prospect.