Objective: To investigate the regulating lipid antioxidation by compound curcumin microcapsule. Method: hyperlipidemia animal model was established

the level t of malondialdehyde(MDA)

nitric oxide(NO)

endothelin(ET-1) etc were measured. Result: Compared with the model group

the low-dose group decreased significantly thelevelof total cholesterol(TC)

Total triglyceride(TG)

ET-1 and the MDA

increased the NO content and superoxide dismutase(SOD)

glutathione peroxidase (GSH-Px)activity

; the high dose group also reduced the TC

TG content

increased SOD and GSH-Px activity

but which have no obvious influence on the content of MDA

NO and ET-1.Compared with curcumin microcapsules

the compound had the pharmacological effects more significantly. Conclusion: The compound microcapsule has significant regulation of the lipid metabolism and antioxidative reaction

the d effect is significantly superior to the single application of curcumin.