Objective:To study effect of compatibility of traditional Chinese medicine pair on decocting rate of main active ingredient. Method: With pair of Scutellaria baicalensis and Coptis chinensis as study object

the content of baicalin and berberine hydrochloride as indexes

which were determined by HPLC

the amount of water

extraction times

extraction time and ratio of S. baicalensis and C. chinensis were chosen as factors

boiling technology was optimized by mixing uniformity design test.Difference of chemical composition between total decoction(with different proportion of S. baicalensis and C. chinensis) and mixed liquid of single decoction of them was investigated

and two target ingredients were visual contrasted by three dimensional response surface and triangle energy level diagram

dynamic change phenomenon of chemical composition was focused on

which due to mixed decoction of S. baicalensis and C. chinensis. Result: The decocting content of main active ingredient from C. chinensis showed significantly correlation with compatibility proportion of S. baicalensis and C. chinensis;But the decocting content of active ingredient from S. baicalensis was concerned with decoction influencing factors.The contents of two index component were lower with other proportions of S. baicalensis and C. chinensis

except the amount of C. chinensis was 2

3

5 times for S. baicalensis. Conclusion: Clinical efficacy of pair-Chinese materia medica could be revealed by study on dynamical change relationship of different compatibility proportions and their chemical composition.