Objective: To evaluate the dynamic changing of troponin(cTn-T) and observe the treatment effect of Guanxin Suhe capsule on acute myocardial infarction(AMI) in rats and investigate its mechanism. Method: Rats were selected to establish acute myocardial infarction model. The rats were divided randomly into five groups and treated with pure water

high-dose Guanxin Suhe (0.8 g·kg-1)

low-dose Guanxin Suhe (0.4 g·kg-1)

captopril respectively for 5 days

then AMI model were established. cTn-T

aspartate aminotransferase(AST)

creatine kinase enzyme(CK)

MBisoenzyme of creatine kinase(CK-MB) was determined after ligating 31 h. Result: The area of myocardial infarction in the Guanxin Suhe capsule high dosage group was reduced

cTn-T and AST decreased

showing a statistical significance compared with the model group (P<0.05

P<0.01

P<0.01).The effect of high-dose and low-dose Guanxin Suhe capsule on ECG in acute myocardial infarction rats was observed

the heights of ST segment were reduced just after ligating 0 h and 31 h. Conclusion: Guanxin Suhe capsule has significant effect on myocardial infarction

it treats myocardial infarction through regulating cTn-T and AST.