Objective: To explore the content changes of serum superoxide-dismutase (SOD) and malondialdehyde (MDA) of chronic superficial gastritis spleen-stomach vacuity cold(CSG-ssvc) patients by moxibustion on ginger therapy of differents moxibustion time. Method: Under the random

contrast and single-blind research method

45 cases who conform to the standard of CSG-ssvc were randomly divided into three groups: the therapy group A (Moxibustion on ginger to the acupoints with 20 minutes) with 15 cases

the therapy group B (moxibustion on ginger to the acupoints with 40 minutes) with 15 cases and the medicine group C (taking medicine of ranitidine) with 15 cases. Moxibustion on ginger to the patients of therapy groups 1 time per day

and the patients of medicine group took ranitidine 0.15 g

2 times per day. Three groups were continuous insist on 10 days for 1 treatment course

took a rest for 1 day and took 2 courses by all. The contens of Anti-oxidation factors were taken by draw blood and test serum on the first day and the 23 rd day. Result: ①All the three groups contents of SOD were significantly augmented after 2 treatment courses

there was a statistically difference when compared to the contents before treatments(P<0.05). And there was a statistically difference when compared to matched the changes of group B and group A

C(P＜0.05). ②All the three groups contents of MDA were significantly decreased after 2(P<0.05)

treatment courses

there was a statistically difference when compared to the contents before treatments but there was no statistically difference compared with three groups. Conclusion: It can increase the contents of SOD and decrease the contents of MDA with both Moxibustion on ginger therapy and taking ranitidine. Moxibustion on ginger therapy for 40 minutes can increase SOD contents significantly

and the results are obviously higer than Moxibustion on ginger therapy for 20 minutes group and taking ranitidine group. Confirmed that Moxibustion on ginger therapy for CSG-ssvc patients has benign regulative the function of enzyme system of produce and remove the oxygen radical. This mechanism may be relevanted to the clinical effect of Moxibustion on ginger therapy for CSG-ssvc patients.