Objective:To observe theinfluence of the joint medication of Ampelopsis japonica root and Aconitum carmichaelii root on the function and pathological morphology of the heart

liver and kidney in rats. Method: Rats were administrated with water decoction of A. japonica and A. carmichaelii for successive 14 days. At thirty minutes after the last administration

the serum levels of total serum protein(TP)

alburnin(Alb)

alanine aminotransferase(ALT)

aspartate aminotransferase (AST)

blood urea nitrogen (BUN)

creatinine (Cr)and lactate dehydrogenase (LDH) were measured. Autopsy was conducted after the death of the rats and the heart

liver

kidney were harvested for pathological examination.The index of viscera was calculated. Result: The levelof ALT and AST (P<0.05)was increased in the A. japonica group; the level of AST (P<0.05) was increased in the aconitum group. When treated with A. japonica and A. carmichaelii jointly

the level of ALT

AST and LDH (P<0.01 or P<0.05)all increased. The examination of organ index showed that the liver index increased(P<0.05) in A. japonica groupo and all the indexes (P<0.01 or P<0.05)of liver and kidney increased when A. japonica and aconitum A. carmichaelii were administrated jointly. Autopsy and histopathological examination indicated that the liver and kidney of the rats changed significantly when A. japonica and A. carmichaelii were administrated jointly. Conclusion: The toxicity of the joint medication of A. carmichaelii japonica and A. carmichaelii in rats would be strengthened.