Objective:To study the effect of the Liuyueqing polysaccharide against CCl4-induced liver fibrosis in rats and its mechanism. Method:SD rats were divided into two groups randomly:hepatic fibrosis model group and normal group. The model group of rats with hepatic fibrosis was established by 1 mL·kg-1 of 50% CCl4

ig

twice per week for continuous 7 weeks. The rats in the normal control group were given normal saline (NS). Sixty SD rats with hepatic fibrosis confirmed by the pathological inspection was randomly divided into LYQP(600

300

150 mg·kg-1) groups

colchicine(0.2 mg·kg-1) group and model group. All rats were treated with drugs or NS for four consecutive weeks by ig

once a day. The activity of alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

and glutathione synthesis(GSH-Px) in serum of rats and the content of hydroxyproline (Hyp) in hepatic tissue were determined. The extent of liver fibrosis was observed by Masson staining. Result:LYQP significantly decreased the activity of ALT and AST in rats with liver fibrosis. Compared with model control group

the content of Hyp in hepatic tissue was decreased significantly. The activity of GSH-Px was significantly increased. Masson staining showed that the collagen fibers in every treated group were less than model control group. Conclusion:Liuyueqing polysaccharide can relieve liver fibrosis induced by CCl4.