Objective:To optimize extraction technology of Cornus officinalis

and investigate its purification technology by macroporous resin. Method: With the content of morroniside as index

the concentration of ethanol

solid-liquid ratio

extraction time and times were selected as factors

extraction technology of total glycosides was optimized by single factor test and orthogonal test.With sampling volume

elution speed

eluent concentration and dosage as factors

single factor test was used to investigate purification technology of C. officinialis with HPD-300 macroporous resin. Result: Optimum extraction technology was as following:extracted 3 times with 50% ethanol of 8 times amount

3 h each time.Purification technology was:eluted with 3 BV 30% ethanol at 1.5 BV·h-1

elution rate of 94.9%. Conclusion: Optimized extracting technology was stable and feasible;It showed that total glycosides from C. officinalis could be effectively purify by HPD-300 macroporous resin.