Objective: To investage optimal preparation technology of compound silymarin-Danshensu dropping pill by solid dispersion technology. Method: PEG 4000

PEG 6000 and Poloxamer 188 were used as carrier material of solid dispersion

compound silymarin-Danshensu dropping pill was prepared by fusion method.With weight difference of dropping pill

roundness and dissolution as indexes

orthogonal design was used to optimize composition of matrix

ratio of drug-matrix

temperature of drug liquid

dropping distance;Cooling agent

cooling temperature

dropping speed and other factors. Result: Optimal technology conditions were as follows:composition of matrix PEG 4000-PEG 6000-Poloxamer 188 as 5: 5: 1

ratio of drug-matrix 1: 2

temperature of dropping drug liquid 90℃

dropping distance 5 cm

dripping rate was 40 drops·min-1

dimethyl-silicone oil as cooling agent

cooling temperature 10-15℃. Conclusion: This optimized process of compound silymarin-Danshensu dropping pill was reasonable and feasible

it had good solubilization effect on main drugs.