As a famous traditional Chinese medicine

Angong Niuhuang Wan is used for treatment of various diseases

such as encephalitis

apoplexy

cerebral hemorrhage

ischemic cerebral injury and so on. It also has unique effect on coma

hyperpyrexia induced by cerebral diseases. Pharmacology studies on Angong Niuhuang Wan reveal its versatile activities on encephalopathy

like cerebral hemorrhage

ischemia injury

sepsis and so on in animals. The safe application of Angong Niuhuang Wan appears to be utmost important due to the contained realgar (As) and cinnabar (Hg). This article describes the progress in studies of Angong Niuhuang Wan

including pharmacologic actions and clinical applications

to provide a new thinking and reference to the further utilization of Angong Niuhuang Wan.