Objective: To investigate the effect of Jiangzhi decoction on lipid levels

vascular endothelial function and hsCRP of Patients with hyperlipidemia. Method: Sixty patients with primary hyperlipidemia were randomly divided into treatment group (n=30) and control group (n=30).The treatment group was treated with lipid-lowering soup side (recipe granules)

once daily. The control group was treated with simvastatin

20 mg once daily

all for 8 weeks. Lipid levels were measured; blood endothelin (ET) was determined by radioimmunoassay; serum nitric oxide (NO) was observed by nitrate reduction method; high-sensitivity C-reactive protein (hs-CRP) was monitored by ELISA; and endothelium-dependent flow-mediated diastolic function (FMD) was also detected. Result: After treatment

in both groups

TC

TG

LDL-C were decreased significantly

HDL-C was increased significantly. No significant difference appeared between the two groups after treatment. In the two groups

ET-1 and hs-CRP were significantly lowered

NO and FMD was significantly increased. ET-1 and FMD of the treatment group showed significant difference compared with those in the control group (P<0.05). Conclusion: Jiangzhi decoction can improve the status of patients with hyperlipidemia. It is likely related to improvement in endothelial function and decrease in plasma hs-CRP level.