Objective: To study the hepatoprotective effect of mogrosides(Mog). Method: Seventy-two mice were randomly divided into six groups: the normal group

the model group

bifendate(BPD) group (0.6 g· kg-1)

high dose Mog group (1.5 g· kg-1)

middle dose Mog group (0.75 g· kg-1) and low dose Mog group (0.38 g· kg-1). Except for normal group and model group

the other mice were orally administered corresponding drugs once per day for seven days.After the last administation

the treated groups and model group were ip given 0.08% CCl4 (10 mL·kg-1) once to produce acute liver injury. The serum was collected after 12 h to detect level of aspartate aminotransferase (AST)

alanine aminotransferase (ALT)

and the histological changes of liver were observed. Seventy-two Wistar rats were randomly divided into six groups: the normal group

the model group

BPD group (0.1 g· kg-1)

high-dose Mog group (0.8 g· kg-1)

middle-dose Mog group (0.4 g· kg-1) and low-dose Mog group (0.2 g·kg-1). Except for normal group the other rats were sc 25%CCl4(2 mL· kg-1) once every two week for eight weeks to establish chronic liver injury (the first time sc 25%CCl4 5 mL· kg-1).The effects of Mog on the activities of ALT and AST

the content of hyaluronic acid(HA)

procollagen Ⅲ N-terminal petide (PⅢNP)

hydroxyproline (Hyp) in serum

the activities of superoxide dismutase(SOD)

glutathione peroxidase(GSH-Px)

the content of malondiadehyde(MDA) in liver tissue was observed. The effect of Mog on transforming growth factor β1(TGF-β1) expression in liver tissue was observed and the histological changes of liver were detected. Result: Mog could inhibit the increasing in ALT and AST in serum of the acute hepatic injury induced by CCl4

and decrease the degree of the histological changes of liver. Mog could significantly decrease the elevation of serum ALT and AST activities

decrease the content of HA

PⅢNP

Hyp in serum; increse the activities of SOD and GSH-Px in liver tissue and decrease the content of MDA in liver tissue in the CCl4-induced chronic liver injury in rat. Mog could inhibit the expression of TGF-β1 and decrease the degree of the histological changes of liver in the CCl4-induced chronic liver injury in rat. Conclusion: Mog showed protective effect on mice with acute hepatic injury; Mog can protect liver function from the chronic hepatic injury induced by CCl4 and has obvious effects of contradicting hepatic fibrosis in rat.