Objective:To optimize flocculation clarification technology conditions of Yilingjing oral liquid by chitosan. Method: Taking absorbance and retention rate of stilbene glucoside as evaluation indicators

influence of the mass concentration of extraction liquid

chitosan dosage

pH

temperature

stirring speed

stirring time and other factors on flocculation effect were investigated.Based on single factor test

orthogonal design was selected to optimize flocculation technology with the mass concentration of extraction liquid

chitosan dosage

flocculation temperature as factors.Flocculation clarification method and alcohol sedimentation were compared. Result: Optimal clarification procedure condition was that the concentration of materials-extraction solution 0.25 g·mL-1

the adding dosage of chitosan of 1.2 mL·g-1

flocculation temperature of 60 ℃

pH of 5.0-5.5

stirring speed of 300 r·min-1 and stirring time of 10 min. Conclusion: Chitosan flocculation method could be used as clarification technology of Yilingjing oral liquid

which could substitute ethanol precipitation method.