Objective:In order to evaluate the effect of developmental toxicity of offspring pregnant rats treated with Curcumae Rhizoma. Method: Wistar female rats were randomized into normal group and blood-stasis model group. A model of blood stasis model in rats by injecting adrenalin and being immersed in ice water was used. The rats were mated and pregnant rats of two groups were randomized into the low

medium and large dose sub-groups and control group.Curcumae Rhizoma were orally administered to pregnant rats from gestational day (GD) 6 through 19 at dose levels of 0

1.4

2.8

5.6 g·kg-1. Physical development and neurobehavioral function were examined. Result: There was a difference of neurobehavioral function toxicity induced by Curcumae Rhizoma between normal and blood-stasis pregnant rats. Compared with the blank group

the pass time of cliff avoidance test and negative geotaxis reflex of normal rats delayed significantly. We could not find any significant changes in that of blood-stasis rats. Conclusion: Neurobehavioral toxicity of offspring of the blood-stasis pregnant rats to Curcumae Rhizoma is weaker than that of the normal pregnant rats

confirmed the rationality of evaluating the toxicity of Chinese medicines based on TCM syndrome theory.