Objective:To study the therapeutic effect of Baiyu Lianyu mixture (BYLY) on diabetes. Method: The mice model of diabetes was induced by intravenous injection of streptozotocin.The diabetes mice were divided into model group

BYLY high dose group (6.0 g·kg-1)

BYLY middle dose group(3.0 g·kg-1)

BYLY low dose group(1.5 g·kg-1

ig) and phenformin group. The drugs were given orally. Blood sugar

glucose tolerance and oxygen-derived free radicals were observed. Result: Compared to the model group

the concentration of fasting blood sugar of the BYLY groups was decreased obviously (P＜0.05

P＜0.01)

the glucose tolerance increased obviously (P＜0.05

P＜0.01).The activity of superoxide dismutase (SOD) and glutathione peroxidase(GSH-Px) increased (P＜0.01)

malondialdehyde (MDA) decreased obviously (P＜0.05

P＜0.01). Conclusion: BYLY shows the effects of decreasing blood sugar

raising glucose tolerance and improving metabolism turbulence of oxygen-derived free radicals on diabetes.