温胆汤对地卓西平马来酸盐诱发精神分裂症模型大鼠脑组织中Cx43 mRNA表达的影响

付艳丽; 万红娇; 朱金华; 马广强

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温胆汤对地卓西平马来酸盐诱发精神分裂症模型大鼠脑组织中Cx43 mRNA表达的影响

更新时间：2024-01-04

- 温胆汤对地卓西平马来酸盐诱发精神分裂症模型大鼠脑组织中Cx43 mRNA表达的影响
- Effect of Wendan Decoction on Connexin 43 mRNA Expression of in Rat Brain Tissue with Schizophrenia Induced by Dizocilpine Maleate
- 中国实验方剂学杂志 2012年18卷第20期页码：173-175
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(81160423);江西省自然科学基金项目(2010GZY0162);江西省卫生厅基金项目(2010Z02)
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- 纸质出版日期：2012
- 稿件说明：
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付艳丽, 万红娇, 朱金华, 等. 温胆汤对地卓西平马来酸盐诱发精神分裂症模型大鼠脑组织中Cx43 mRNA表达的影响[J]. 中国实验方剂学杂志, 2012,18(20):173-175.

FU Yan-li, WAN Hong-jiao, ZHU Jin-hua, et al. Effect of Wendan Decoction on Connexin 43 mRNA Expression of in Rat Brain Tissue with Schizophrenia Induced by Dizocilpine Maleate[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 173-175.
付艳丽, 万红娇, 朱金华, 等. 温胆汤对地卓西平马来酸盐诱发精神分裂症模型大鼠脑组织中Cx43 mRNA表达的影响[J]. 中国实验方剂学杂志, 2012,18(20):173-175. DOI：

FU Yan-li, WAN Hong-jiao, ZHU Jin-hua, et al. Effect of Wendan Decoction on Connexin 43 mRNA Expression of in Rat Brain Tissue with Schizophrenia Induced by Dizocilpine Maleate[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(20): 173-175. DOI：

摘要

目的: 探讨温胆汤对精神分裂症模型大鼠脑组织中神经胶质细胞连接蛋白(Cx43) mRNA的影响。方法: 将健康的SD大鼠50只随机分为5组:正常组(A)、模型组(B)、温胆汤高、中、低剂量组(C

E组

剂量为生药40

10 g·kg-1)。A

B组生理盐水ig

E组温胆汤ig

1次/d

21 d后

按照0.6 mg·kg-1一次性ip地卓西平马来酸盐(MK-8O1)建立拟精神分裂症模型

然后行为学观察3 d

处死大鼠。应用逆转录聚合酶链式反应(RT-PCR)法

检测大鼠Cx43 mRNA的表达量。结果: 模型组Cx43 mRNA的表达量低于正常组

有显著性意义(P<0.05);温胆汤3个剂量组Cx43 mRNA的表达量明显高于模型组

有显著性意义(P<0.05)。结论: 温胆汤能够增强精神分裂症模型大鼠脑组织中Cx43 mRNA的表达。

Abstract

Objective:To study the effect of Wendan decoction on connexin 43(Cx43) mRNA expression in brain tissue of rats with schizophrenia. Method: Fifty SD rats were divided five groups by random

including normal group(A)

model group(B)

Wendan decoction high-dosage group(C)

medium-dosage group(D) and low-dosage group(E)

respectively. The A and B groups were given normal saline and the C

E groups were given Wendan decoction(40

10 g·kg-1) every day

which lasted for 21 days. Dizocilpine maleate(MK-801) 0.6 mg·kg-1 was ip given to establishthe rat schizophrenic model. Then rat behaviors were observed for 3 days all rats were sacrificed. Then RT-PCR method was used to detect Cx43 mRNA expression in the nervecells of the every group rats. Result: The Cx43 mRNA expression of group B was lower than that of group A (P<0.05).And the Cx43 mRNA expression of group C

D and E was rose compared with that of group B(P<0.05). Conclusion: Wendan decoction can reinforce the expression of Cx43 mRNA in the brain tissue of rats with schizophrenia.

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